Positive regulation of mesenchymal cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of mesenchymal cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSC1, NKIRAS2, and TMUB2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TSC1 grouped by Positive regulation of mesenchymal cell proliferation-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TSC1 →	-1.070	-0.258	.002	.001	3	3
UPPER_AERODIGESTIVE_TRACT	NKIRAS2 →	-0.894	-0.273	<.001	.001	2	4
UPPER_AERODIGESTIVE_TRACT	TMUB2 →	-0.905	-0.268	.004	.001	3	3
UPPER_AERODIGESTIVE_TRACT	ZNF830 →	-1.049	-0.232	.002	.002	3	3
UPPER_AERODIGESTIVE_TRACT	C6orf47 →	-0.552	-0.210	.006	.009	3	3
UPPER_AERODIGESTIVE_TRACT	PWP2 →	-1.936	-0.255	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TSC1 by Positive regulation of mesenchymal cell proliferation activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →