Positive regulation of neuroblast proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of neuroblast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGEF25, VCAN, and JAM3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of neuroblast proliferation activity versus ARHGEF25 in PDAC (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ARHGEF25 →	+0.406	+0.430	<.001	.002	3	7
CCRCC	VCAN →	+1.227	+0.327	<.001	.005	2	8
UCEC	JAM3 →	+0.655	+0.354	<.001	<.001	3	6
UCEC	NUAK1 →	+0.605	+0.343	.001	.002	3	6
LSCC	BOC →	+0.808	+0.261	<.001	.008	3	5
OV	MFAP5 →	+1.291	+0.615	.006	.004	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002052 vs ARHGEF25 — PDAC

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