Positive regulation of neuroblast proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of neuroblast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FRMD6, SNAPC1, and BCAP29, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FRMD6 grouped by Positive regulation of neuroblast proliferation-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	FRMD6 →	-3.453	-1.092	<.001	.004	3	6
LIVER	SNAPC1 →	-2.083	-1.417	<.001	.002	3	6
LIVER	BCAP29 →	-1.126	-1.286	<.001	.005	3	5
LIVER	CD59 →	-2.137	-1.233	<.001	<.001	3	5
STOMACH	ANKRD33B →	-0.953	-0.695	.002	.009	3	5
LARGE_INTESTINE	FXYD3 →	+2.847	+0.662	.007	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FRMD6 by Positive regulation of neuroblast proliferation activity — LIVER

Explore this box plot interactively →