Positive regulation of neuroblast proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of neuroblast proliferation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DVL1, GCFC2, and PRDM1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DVL1 grouped by Positive regulation of neuroblast proliferation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	DVL1 →	+0.280	+1.719	.001	<.001	3	3
LUNG_SCLC	GCFC2 →	-0.194	-0.953	<.001	.009	3	3
BLOOD_Leukemia	PRDM1 →	+0.272	+1.735	.006	<.001	3	3
OESOPHAGUS	PDE6H →	+0.116	+0.279	.004	.001	3	3
OESOPHAGUS	MCRS1 →	+0.291	+0.239	<.001	.008	3	3
PANCREAS	PLAUR →	-0.294	-1.477	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DVL1 by Positive regulation of neuroblast proliferation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →