Blood vessel endothelial cell proliferation involved in sprouting angiogenesis

Across TCGA patient cohorts, RNA activity of the Blood vessel endothelial cell proliferation involved in sprouting angiogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CD93, MMRN2, and F13A1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Blood vessel endothelial cell proliferation involved in sprouting angiogenesis activity versus CD93 in CCRCC (Pearson r = 0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CD93 →	+0.574	+0.074	<.001	<.001	3	8
CCRCC	MMRN2 →	+0.632	+0.087	<.001	<.001	3	8
UCEC	F13A1 →	+0.556	+0.061	<.001	<.001	3	8
UCEC	NGFR_T293 →	+1.039	+0.056	.001	.001	3	7
BRCA	RECK →	+0.603	+0.050	<.001	<.001	3	7
UCEC	STAB1 →	+0.406	+0.057	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002043 vs CD93 — CCRCC

Explore this scatter interactively →