Cell migration involved in sprouting angiogenesis

Across TCGA patient cohorts, RNA activity of the Cell migration involved in sprouting angiogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LAMC1, RSU1, and SSC5D, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell migration involved in sprouting angiogenesis activity versus LAMC1 in OV (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LAMC1 →	+0.417	+0.059	.001	<.001	3	10
UCEC	RSU1 →	+0.614	+0.088	<.001	<.001	3	10
BRCA	SSC5D →	+0.881	+0.045	<.001	<.001	3	10
UCEC	BGN →	+0.724	+0.072	<.001	<.001	3	10
UCEC	LAMA4 →	+0.707	+0.076	<.001	<.001	3	10
OV	LAMB1 →	+0.458	+0.044	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002042 vs LAMC1 — OV

Explore this scatter interactively →