Cell migration involved in sprouting angiogenesis

Across TCGA cell cohorts, RNA activity of the Cell migration involved in sprouting angiogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADGRB3, RPL14, and H2AZ2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADGRB3 grouped by Cell migration involved in sprouting angiogenesis-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADGRB3 →	+0.146	+0.714	.008	.005	3	4
SOFT_TISSUE	RPL14 →	-0.701	-0.216	.005	.004	3	4
LUNG_NSCLC_LUSC	H2AZ2 →	-0.430	-1.319	.002	.001	3	4
STOMACH	FAM216A →	-0.172	-0.255	.003	.001	3	4
LUNG_NSCLC_LUAD	RWDD1 →	+0.160	+0.461	.002	.009	3	3
LUNG_NSCLC_LUAD	DCUN1D2 →	-0.124	-0.370	.002	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADGRB3 by Cell migration involved in sprouting angiogenesis activity — LARGE_INTESTINE

Explore this box plot interactively →