Cell migration involved in sprouting angiogenesis

Across TCGA cell cohorts, RNA activity of the Cell migration involved in sprouting angiogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CATSPERB, SLC25A16, and ST3GAL2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CATSPERB grouped by Cell migration involved in sprouting angiogenesis-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CATSPERB →	+0.737	+0.720	.001	.001	3	4
BREAST	SLC25A16 →	+0.718	+0.403	.002	.006	3	3
BREAST	ST3GAL2 →	-0.811	-0.442	.007	.002	3	3
BREAST	PJA1 →	-0.975	-0.628	.003	.003	2	4
BREAST	SYCP2 →	+1.839	+0.465	.001	.001	3	3
BREAST	LIX1L →	-1.413	-0.488	.008	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CATSPERB by Cell migration involved in sprouting angiogenesis activity — LUNG_NSCLC_LUAD

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