Sprouting angiogenesis

Across TCGA patient cohorts, RNA activity of the Sprouting angiogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BGN, COL6A3, and F13A1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sprouting angiogenesis activity versus BGN in UCEC (Pearson r = 0.55).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BGN →	+0.810	+0.047	<.001	<.001	3	10
GBM	COL6A3 →	+0.999	+0.036	<.001	<.001	3	10
GBM	F13A1 →	+0.769	+0.035	<.001	<.001	3	10
UCEC	LAMA4 →	+0.685	+0.052	<.001	<.001	3	10
GBM	LAMB1 →	+0.587	+0.042	.002	<.001	3	10
CCRCC	MMRN2 →	+0.641	+0.065	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002040 vs BGN — UCEC

Explore this scatter interactively →