Sprouting angiogenesis

Across TCGA patient cohorts, RNA activity of the Sprouting angiogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JCAD, SPARC, and CNRIP1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sprouting angiogenesis activity versus JCAD in OV (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	JCAD →	+1.169	+1.024	<.001	<.001	3	9
LSCC	SPARC →	+1.297	+1.172	.001	.005	3	8
UCEC	CNRIP1 →	+1.339	+1.626	<.001	<.001	3	8
OV	BGN →	+1.438	+0.651	<.001	<.001	3	8
OV	FKBP7 →	+0.736	+1.000	.003	<.001	3	8
BRCA	MEIS3 →	+1.106	+0.581	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002040 vs JCAD — OV

Explore this scatter interactively →