Sprouting angiogenesis

Across TCGA cell cohorts, RNA activity of the Sprouting angiogenesis pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNS3, ZNF862, and ETV3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KCNS3 grouped by Sprouting angiogenesis-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	KCNS3 →	+1.580	+1.064	.003	.002	3	4
UPPER_AERODIGESTIVE_TRACT	ZNF862 →	+1.474	+1.022	<.001	.001	3	3
UPPER_AERODIGESTIVE_TRACT	ETV3 →	+0.842	+1.427	.002	.003	3	3
UPPER_AERODIGESTIVE_TRACT	TUBG2 →	+1.051	+1.022	.004	.001	3	3
CNS	TRIM2 →	+1.012	+0.635	.001	.009	3	3
CNS	NSRP1 →	+0.365	+0.685	.005	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KCNS3 by Sprouting angiogenesis activity — KIDNEY

Explore this box plot interactively →