Regulation of L-glutamate import across plasma membrane

Across TCGA patient cohorts, RNA activity of the Regulation of L-glutamate import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the UCS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPM1A, ARHGAP5, and NUMB, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of L-glutamate import across plasma membrane activity versus PPM1A in UCS (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	PPM1A →	+0.800	+0.086	<.001	<.001	3	29
THYM	ARHGAP5 →	+1.296	+0.095	<.001	<.001	3	29
CHOL	NUMB →	+0.915	+0.086	<.001	<.001	2	29
DLBC	TOGARAM1 →	+1.054	+0.071	<.001	<.001	3	28
DLBC	HECTD1 →	+1.205	+0.059	<.001	<.001	3	28
DLBC	KIAA0586 →	+0.780	+0.063	<.001	<.001	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002036 vs PPM1A — UCS

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