Regulation of L-glutamate import across plasma membrane

Across TCGA patient cohorts, RNA activity of the Regulation of L-glutamate import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CA4, RPL36AP13, and HK2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of L-glutamate import across plasma membrane activity versus CA4 in GBM (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CA4 →	+0.591	+0.516	<.001	.009	3	3
COAD	RPL36AP13 →	+0.463	+0.687	<.001	<.001	3	2
UCEC	HK2 →	-0.780	-0.622	.001	<.001	3	2
LUAD	PNMA8A →	-0.860	-0.499	<.001	.003	3	2
UCEC	GSTA9P →	-1.369	-0.658	<.001	<.001	3	2
PDAC	AFG3L2 →	-0.261	-0.220	.006	.008	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002036 vs CA4 — GBM

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