Regulation of L-glutamate import across plasma membrane

Across TCGA cell cohorts, RNA activity of the Regulation of L-glutamate import across plasma membrane pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC17A8, CD28, and TNF, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC17A8 grouped by Regulation of L-glutamate import across plasma membrane-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SLC17A8 →	-0.444	-1.569	<.001	<.001	3	13
SOFT_TISSUE	CD28 →	+0.326	+1.716	.006	<.001	3	6
LIVER	TNF →	-0.219	-1.622	.001	<.001	3	5
OVARY	PHTF1 →	-0.183	-1.382	<.001	<.001	2	6
UPPER_AERODIGESTIVE_TRACT	EIF5A2 →	+0.213	+1.238	.002	.001	3	4
SOFT_TISSUE	PICALM →	-0.258	-1.214	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC17A8 by Regulation of L-glutamate import across plasma membrane activity — SOFT_TISSUE

Explore this box plot interactively →