Regulation of L-glutamate import across plasma membrane

Across TCGA cell cohorts, RNA activity of the Regulation of L-glutamate import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL39, ZFYVE9, and KIF1B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPL39 grouped by Regulation of L-glutamate import across plasma membrane-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RPL39 →	-0.572	-1.221	.009	<.001	3	4
URINARY_TRACT	ZFYVE9 →	-0.796	-1.807	.002	<.001	3	4
URINARY_TRACT	KIF1B →	-0.840	-1.807	.004	<.001	3	4
BONE	SIPA1L1 →	-0.972	-1.179	<.001	.007	3	4
KIDNEY	CAPZA1 →	-0.744	-1.442	.004	.005	3	3
KIDNEY	GTF3A →	-0.830	-1.420	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPL39 by Regulation of L-glutamate import across plasma membrane activity — STOMACH

Explore this box plot interactively →