Regulation of L-glutamate import across plasma membrane

Across TCGA cell cohorts, RNA activity of the Regulation of L-glutamate import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARL6IP5, PER2, and ITGB1, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of L-glutamate import across plasma membrane activity versus ARL6IP5 in BLOOD_Myeloma (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ARL6IP5 →	+1.835	+0.275	<.001	<.001	3	19
LIVER	PER2 →	-1.160	-0.283	<.001	<.001	3	15
BONE	ITGB1 →	+2.124	+0.203	.001	<.001	3	14
BONE	ANO10 →	+1.417	+0.153	<.001	<.001	3	13
BONE	C19orf48 →	-0.973	-0.194	.004	<.001	3	13
LUNG_NSCLC_LUSC	GLB1 →	+0.970	+0.243	.002	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002036 vs ARL6IP5 — BLOOD_Myeloma

Explore this scatter interactively →