Regulation of L-glutamate import across plasma membrane

Across TCGA cell cohorts, RNA activity of the Regulation of L-glutamate import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARL6IP5, LAMP1, and SERPINH1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of L-glutamate import across plasma membrane activity versus ARL6IP5 in LUNG_NSCLC_LUAD (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ARL6IP5 →	+0.719	+0.099	.001	.002	3	7
LUNG_NSCLC_LUAD	LAMP1 →	+0.713	+0.124	.004	<.001	3	7
BLOOD_Lymphoma	SERPINH1 →	+1.839	+0.376	.002	.008	3	7
PANCREAS	CENPV →	-1.356	-0.241	.005	.004	3	7
LARGE_INTESTINE	PAM16 →	-0.664	-0.175	.002	.007	2	8
CNS	RPL10A →	-0.574	-0.197	.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002036 vs ARL6IP5 — LUNG_NSCLC_LUAD

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