G protein-coupled receptor internalization

Across TCGA patient cohorts, RNA activity of the G protein-coupled receptor internalization pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ERF_T526, ATP6AP2, and GRIPAP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, G protein-coupled receptor internalization activity versus ERF_T526 in OV (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ERF_T526 →	-0.503	-0.046	<.001	<.001	3	5
GBM	ATP6AP2 →	+0.276	+0.074	<.001	<.001	3	4
LSCC	GRIPAP1 →	+0.173	+0.073	.001	<.001	3	4
LSCC	CDK18_S132 →	+0.626	+0.063	<.001	<.001	3	4
OV	MAP1B_S1396 →	-1.017	-0.069	.003	.008	3	4
UCEC	EMSY_S195 →	-0.432	-0.073	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002031 vs ERF_T526 — OV

Explore this scatter interactively →