G protein-coupled receptor internalization

Across TCGA patient cohorts, RNA activity of the G protein-coupled receptor internalization pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARRB1, IL16, and IGSF6, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, G protein-coupled receptor internalization activity versus ARRB1 in HNSC (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ARRB1 →	+0.493	+0.133	<.001	<.001	3	8
LSCC	IL16 →	+0.693	+0.108	<.001	.007	3	7
UCEC	IGSF6 →	+0.422	+0.148	.003	.001	3	7
UCEC	TNFAIP8L2 →	+0.595	+0.165	<.001	<.001	3	7
HNSC	CYTH4 →	+0.860	+0.186	.002	<.001	3	6
HNSC	GRAP2 →	+0.697	+0.184	.006	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002031 vs ARRB1 — HNSC

Explore this scatter interactively →