G protein-coupled receptor internalization

Across TCGA cell cohorts, RNA activity of the G protein-coupled receptor internalization pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLIC1, SPI1, and ROBO3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CLIC1 grouped by G protein-coupled receptor internalization-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CLIC1 →	-1.272	-1.843	.001	<.001	3	5
SKIN	SPI1 →	+0.135	+1.112	<.001	<.001	3	5
LIVER	ROBO3 →	-2.531	-1.466	.003	.003	3	5
LIVER	TSPAN12 →	+1.935	+1.333	.005	.007	3	5
LIVER	ADCY6 →	+1.551	+2.183	<.001	<.001	3	5
LARGE_INTESTINE	PRR12 →	+0.652	+1.062	.006	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CLIC1 by G protein-coupled receptor internalization activity — SOFT_TISSUE

Explore this box plot interactively →