G protein-coupled receptor internalization

Across TCGA cell cohorts, RNA activity of the G protein-coupled receptor internalization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZIC2, NPHS1, and STPG2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, G protein-coupled receptor internalization activity versus ZIC2 in LUNG_SCLC (Pearson r = -0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ZIC2 →	-3.367	-1.259	<.001	.007	3	3
LUNG_SCLC	NPHS1 →	+1.627	+2.144	<.001	.003	3	2
LUNG_SCLC	STPG2 →	+0.192	+1.235	.003	.009	3	2
LUNG_SCLC	HOXA10 →	-3.198	-1.838	.009	.007	3	2
BLOOD_Leukemia	SEPTIN3 →	-1.449	-1.136	<.001	.002	3	2
BLOOD_Leukemia	FBXW9 →	+0.726	+1.153	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002031 vs ZIC2 — LUNG_SCLC

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