Regulation of heart rate

Across TCGA patient cohorts, RNA activity of the Regulation of heart rate pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKR1B15, DSP, and KRT5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of heart rate activity versus AKR1B15 in HNSC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	AKR1B15 →	+0.793	+0.801	.002	.001	3	4
LSCC	DSP →	+1.840	+0.942	<.001	<.001	3	4
LSCC	KRT5 →	+2.690	+0.536	<.001	.007	3	3
LSCC	RNU6-167P →	+1.466	+0.514	<.001	.004	3	3
OV	APOBEC3H →	-0.836	-0.607	<.001	.003	3	3
OV	NCF4 →	-0.912	-0.559	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002027 vs AKR1B15 — HNSC

Explore this scatter interactively →