Regulation of heart rate

Across TCGA cell cohorts, RNA activity of the Regulation of heart rate pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNIP2, ZNF547, and PCMTD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KCNIP2 grouped by Regulation of heart rate-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KCNIP2 →	+0.493	+0.995	.001	<.001	3	3
SOFT_TISSUE	ZNF547 →	+0.501	+1.160	.002	.001	3	3
SOFT_TISSUE	PCMTD1 →	+1.221	+1.165	.008	<.001	3	3
SOFT_TISSUE	ZNF519 →	+1.061	+1.152	.008	.001	2	4
BLOOD_Leukemia	PLAAT4 →	+2.336	+0.526	<.001	.006	2	4
KIDNEY	ELOA2 →	+0.028	+0.900	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KCNIP2 by Regulation of heart rate activity — SOFT_TISSUE

Explore this box plot interactively →