Regulation of heart rate

Across TCGA cell cohorts, RNA activity of the Regulation of heart rate pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALS2CL, MPZL2, and PRRG2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of heart rate activity versus ALS2CL in STOMACH (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ALS2CL →	+3.455	+0.399	<.001	.001	3	8
URINARY_TRACT	MPZL2 →	+5.202	+0.472	.001	.006	3	7
URINARY_TRACT	PRRG2 →	+2.357	+0.480	<.001	<.001	3	7
STOMACH	DIXDC1 →	-1.485	-0.359	.002	<.001	3	7
STOMACH	PKP2 →	+2.564	+0.364	.001	.004	3	7
STOMACH	FXYD3 →	+5.514	+0.371	<.001	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002027 vs ALS2CL — STOMACH

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