Regulation of the force of heart contraction

Across TCGA patient cohorts, RNA activity of the Regulation of the force of heart contraction pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AK4, CHAMP1, and NOL3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of the force of heart contraction activity versus AK4 in HNSC (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	AK4 →	+0.577	+0.067	<.001	.005	3	7
BRCA	CHAMP1 →	-0.261	-0.064	.001	<.001	3	6
OV	NOL3 →	+0.331	+0.038	.006	.003	3	6
BRCA	LOXL2 →	+0.667	+0.059	<.001	<.001	3	6
GBM	NTHL1 →	-0.437	-0.050	<.001	<.001	3	6
GBM	UBTF →	-0.281	-0.065	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002026 vs AK4 — HNSC

Explore this scatter interactively →