Regulation of the force of heart contraction

Across TCGA cell cohorts, RNA activity of the Regulation of the force of heart contraction pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF13B, SLC34A3, and SYDE1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KIF13B grouped by Regulation of the force of heart contraction-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KIF13B →	+1.426	+1.108	.001	.005	3	4
LIVER	SLC34A3 →	+0.232	+1.676	.001	<.001	3	4
URINARY_TRACT	SYDE1 →	-3.643	-2.001	<.001	<.001	3	4
SOFT_TISSUE	AURKAIP1 →	-0.790	-1.657	.001	<.001	3	4
SOFT_TISSUE	ERI2 →	+0.906	+1.281	<.001	.004	3	4
CNS	LYSMD1 →	+0.614	+0.768	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIF13B by Regulation of the force of heart contraction activity — LUNG_SCLC

Explore this box plot interactively →