Diet induced thermogenesis

Across TCGA cell cohorts, RNA activity of the Diet induced thermogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLEKHJ1, ACTL6A, and BMERB1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Diet induced thermogenesis activity versus PLEKHJ1 in OESOPHAGUS (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PLEKHJ1 →	+0.854	+1.618	.003	.001	3	3
LUNG_SCLC	ACTL6A →	+1.105	+1.262	.009	.004	3	3
LUNG_SCLC	BMERB1 →	+3.242	+1.265	.001	.003	3	3
LUNG_SCLC	RPL35A →	+0.742	+0.863	.006	.005	2	4
LUNG_SCLC	AGBL5 →	+0.730	+1.211	.004	.003	3	3
LARGE_INTESTINE	PRKCD →	+0.698	+1.095	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002024 vs PLEKHJ1 — OESOPHAGUS

Explore this scatter interactively →