Reduction of food intake in response to dietary excess

Across TCGA patient cohorts, RNA activity of the Reduction of food intake in response to dietary excess pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STRBP, AGO3, and DNMT1_S143, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Reduction of food intake in response to dietary excess activity versus STRBP in LUAD (Pearson r = 0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	STRBP →	+0.229	+0.078	.004	<.001	3	5
LSCC	AGO3 →	-0.209	-0.094	<.001	<.001	3	5
PDAC	DNMT1_S143 →	+0.554	+0.120	<.001	<.001	3	5
PDAC	EZH2_S380 →	+0.497	+0.105	<.001	<.001	3	5
LSCC	POLD3 →	+0.380	+0.120	<.001	<.001	3	5
UCEC	GNB1 →	-0.396	-0.189	.005	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002023 vs STRBP — LUAD

Explore this scatter interactively →