Reduction of food intake in response to dietary excess

Across TCGA cell cohorts, RNA activity of the Reduction of food intake in response to dietary excess pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WHRN, RAB5B, and SLC26A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WHRN grouped by Reduction of food intake in response to dietary excess-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	WHRN →	-1.823	-1.126	.008	.006	3	5
STOMACH	RAB5B →	-0.806	-1.557	.001	.001	3	4
STOMACH	SLC26A1 →	-1.274	-1.389	.002	.003	3	4
BREAST	VMAC →	-0.554	-0.705	.004	.004	3	4
LUNG_SCLC	METTL26 →	+0.874	+0.927	.004	.007	2	4
LUNG_NSCLC_LUAD	COLEC11 →	-0.733	-1.306	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WHRN by Reduction of food intake in response to dietary excess activity — STOMACH

Explore this box plot interactively →