Reduction of food intake in response to dietary excess

Across TCGA cell cohorts, RNA activity of the Reduction of food intake in response to dietary excess pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GDF15, BBC3, and CDKN1A, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Reduction of food intake in response to dietary excess activity versus GDF15 in SKIN (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GDF15 →	+4.701	+0.669	<.001	<.001	3	20
STOMACH	BBC3 →	+1.747	+1.064	<.001	.004	2	17
BONE	CDKN1A →	+2.615	+1.103	<.001	<.001	3	15
LUNG_NSCLC_LUAD	PGPEP1 →	+1.497	+1.440	<.001	<.001	3	12
LUNG_NSCLC_LUSC	TUBB →	-1.482	-2.028	.005	<.001	3	12
URINARY_TRACT	KIF20A →	-1.191	-1.170	<.001	.002	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002023 vs GDF15 — SKIN

Explore this scatter interactively →