Response to dietary excess

Across TCGA patient cohorts, RNA activity of the Response to dietary excess pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TFF3, KLHDC9, and MOAP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to dietary excess activity versus TFF3 in BRCA (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TFF3 →	+3.784	+0.343	<.001	.001	3	4
LUAD	KLHDC9 →	+0.740	+0.326	<.001	.001	3	4
GBM	MOAP1 →	+0.424	+0.299	<.001	<.001	3	4
LUAD	REEP4 →	-0.310	-0.271	.004	.006	2	5
UCEC	TPX2 →	-0.955	-0.482	<.001	.001	3	4
UCEC	CLSPN →	-0.392	-0.449	.008	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002021 vs TFF3 — BRCA

Explore this scatter interactively →