Response to dietary excess

Across TCGA cell cohorts, RNA activity of the Response to dietary excess pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRPV1, RCOR2, and ADRB1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRPV1 grouped by Response to dietary excess-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TRPV1 →	-0.251	-1.230	.008	.005	1	7
BLOOD_Leukemia	RCOR2 →	-0.146	-1.278	.005	.003	3	5
SOFT_TISSUE	ADRB1 →	-0.280	-1.185	.002	.001	3	5
BONE	LIN7B →	-0.426	-1.907	.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	GP1BB →	-0.123	-0.928	<.001	.004	3	5
BLOOD_Leukemia	SORL1 →	-0.301	-1.205	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRPV1 by Response to dietary excess activity — SOFT_TISSUE

Explore this box plot interactively →