Regulation of blood volume by renin-angiotensin

Across TCGA patient cohorts, RNA activity of the Regulation of blood volume by renin-angiotensin pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HSPA12B, TNS2_S102, and HEATR1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of blood volume by renin-angiotensin activity versus HSPA12B in HNSC (Pearson r = 0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HSPA12B →	+0.320	+0.315	<.001	.005	3	6
OV	TNS2_S102 →	+0.684	+0.062	<.001	<.001	3	6
CCRCC	HEATR1 →	-0.208	-0.079	<.001	.004	3	6
GBM	TMOD2 →	+0.451	+0.113	.002	.006	3	5
GBM	UTP6 →	-0.212	-0.118	<.001	<.001	3	5
HNSC	BOP1 →	-0.252	-0.303	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002016 vs HSPA12B — HNSC

Explore this scatter interactively →