Regulation of blood volume by renin-angiotensin

Across TCGA cell cohorts, RNA activity of the Regulation of blood volume by renin-angiotensin pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGT, ZNF451, and PRODH, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AGT grouped by Regulation of blood volume by renin-angiotensin-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AGT →	-0.389	-1.351	.001	.002	3	14
LUNG_NSCLC_LUAD	ZNF451 →	+0.163	+0.961	.002	.001	3	5
CNS	PRODH →	+0.128	+0.757	.002	.001	3	5
LUNG_NSCLC_LUAD	CHRM2 →	-0.221	-1.069	<.001	<.001	3	5
BLOOD_Myeloma	TACR1 →	-0.292	-1.553	.001	.001	3	5
BREAST	RPS6KA2 →	-0.222	-0.982	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AGT by Regulation of blood volume by renin-angiotensin activity — BLOOD_Leukemia

Explore this box plot interactively →