Morphogenesis of an epithelial sheet

Across TCGA cell cohorts, RNA activity of the Morphogenesis of an epithelial sheet pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GCLC, TARDBP, and DPYS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GCLC grouped by Morphogenesis of an epithelial sheet-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GCLC →	+0.425	+1.590	.007	<.001	3	3
BLOOD_Leukemia	TARDBP →	-0.252	-0.860	<.001	.005	3	3
BLOOD_Leukemia	DPYS →	+0.161	+1.133	.002	.003	3	3
BLOOD_Leukemia	CECR2 →	+0.234	+0.247	.001	<.001	3	3
KIDNEY	P3H1 →	-0.158	-0.248	.002	.006	2	4
KIDNEY	KLC4 →	-0.170	-0.354	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GCLC by Morphogenesis of an epithelial sheet activity — BLOOD_Lymphoma

Explore this box plot interactively →