Morphogenesis of an epithelial sheet

Across TCGA cell cohorts, RNA activity of the Morphogenesis of an epithelial sheet pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NRP1, ITGA5, and RAB11FIP4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Morphogenesis of an epithelial sheet activity versus NRP1 in BONE (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	NRP1 →	+4.282	+0.497	<.001	.005	3	8
CNS	ITGA5 →	+1.726	+0.187	.002	.002	3	8
OVARY	RAB11FIP4 →	-3.086	-0.440	.003	.002	3	7
BREAST	ITGB1 →	+2.010	+0.405	<.001	<.001	3	7
BONE	CD44 →	+5.862	+0.511	<.001	.002	3	7
BONE	BTG2 →	-3.284	-0.622	.002	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002011 vs NRP1 — BONE

Explore this scatter interactively →