Regulation of angiotensin levels in blood

Across TCGA cell cohorts, RNA activity of the Regulation of angiotensin levels in blood pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANO10, ZCCHC24, and SLC46A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ANO10 grouped by Regulation of angiotensin levels in blood-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ANO10 →	-3.035	-2.337	.003	.006	3	5
BLOOD_Lymphoma	ZCCHC24 →	-3.454	-2.269	.004	.009	2	6
BLOOD_Lymphoma	SLC46A1 →	-3.235	-2.337	.004	.006	3	4
CNS	MICU1 →	-0.589	-0.967	<.001	<.001	3	4
LUNG_NSCLC_LUSC	POLI →	-1.280	-1.000	<.001	.006	3	4
LUNG_NSCLC_LUSC	HOXA1 →	+1.745	+1.583	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ANO10 by Regulation of angiotensin levels in blood activity — BLOOD_Lymphoma

Explore this box plot interactively →