Renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure

Across TCGA patient cohorts, RNA activity of the Renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are F2R, EDNRB, and F2RL1, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure activity versus F2R in THYM (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	F2R →	+2.491	+0.079	<.001	<.001	3	29
UVM	EDNRB →	+1.764	+0.165	<.001	<.001	3	25
LAML	F2RL1 →	+1.663	+0.140	<.001	<.001	3	25
THYM	SEPTIN11 →	+1.269	+0.070	<.001	<.001	3	23
THYM	PTPRG →	+1.432	+0.078	<.001	<.001	3	23
LAML	CALCRL →	+1.516	+0.127	<.001	<.001	3	23

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001999 vs F2R — THYM

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