Renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure

Across TCGA patient cohorts, RNA activity of the Renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CNRIP1, HSPA12B, and KANK2_S540, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure activity versus CNRIP1 in UCEC (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CNRIP1 →	+0.517	+0.065	.005	.004	3	8
BRCA	HSPA12B →	+0.340	+0.043	<.001	<.001	3	8
BRCA	KANK2_S540 →	+0.705	+0.070	<.001	<.001	3	8
BRCA	KANK3 →	+0.729	+0.059	<.001	<.001	3	8
BRCA	ASPA →	+0.745	+0.058	<.001	<.001	3	7
BRCA	SH3D19 →	+0.352	+0.052	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001999 vs CNRIP1 — UCEC

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