Renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure

pathway activity — cross-omics
GO:0001999Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are YY2, SMIM17, and RUNX2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECYY2 →+0.413+0.336.008<.00134
GBMSMIM17 →+0.601+0.496<.001.00334
GBMRUNX2 →-0.591-0.325<.001.00633
LSCCZNF449 →+0.351+0.589.002.00733
COADGLIPR1L2 →+0.250+0.167.008.00333
LUADCORO2A →-0.495-0.156.006<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration