Renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure

Across TCGA cell cohorts, RNA activity of the Renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAG3, SENP2, and ACAT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LAG3 grouped by Renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	LAG3 →	+0.390	+2.034	.003	.001	2	5
OESOPHAGUS	SENP2 →	+1.067	+0.479	<.001	.006	3	3
LUNG_SCLC	ACAT1 →	+1.431	+0.935	<.001	.004	3	3
LUNG_NSCLC_LUAD	REEP4 →	+0.505	+0.895	.004	<.001	3	3
LUNG_NSCLC_LUAD	BPTF →	+0.712	+0.811	<.001	.005	3	3
BREAST	ARHGEF18 →	-0.702	-1.031	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LAG3 by Renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure activity — CNS

Explore this box plot interactively →