Regulation of systemic arterial blood pressure by norepinephrine-epinephrine

Across TCGA patient cohorts, RNA activity of the Regulation of systemic arterial blood pressure by norepinephrine-epinephrine pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SSB, NDUFA9, and PTPRC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of systemic arterial blood pressure by norepinephrine-epinephrine activity versus SSB in LSCC (Pearson r = -0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SSB →	-0.366	-0.136	<.001	<.001	3	5
PDAC	NDUFA9 →	+0.273	+0.096	<.001	.001	3	5
LSCC	PTPRC →	+0.627	+0.133	<.001	<.001	3	5
GBM	ADNP →	-0.473	-0.119	<.001	<.001	3	5
GBM	ESF1 →	-0.301	-0.082	.001	.005	3	5
GBM	NONO →	-0.265	-0.103	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001993 vs SSB — LSCC

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