Regulation of systemic arterial blood pressure by norepinephrine-epinephrine

Across TCGA patient cohorts, RNA activity of the Regulation of systemic arterial blood pressure by norepinephrine-epinephrine pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GALNT16, MYL9, and PLEKHA4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of systemic arterial blood pressure by norepinephrine-epinephrine activity versus GALNT16 in HNSC (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GALNT16 →	+0.584	+0.574	.001	<.001	3	4
COAD	MYL9 →	+1.415	+0.284	<.001	<.001	3	4
COAD	PLEKHA4 →	+0.655	+0.227	.001	<.001	3	4
COAD	RERGL →	+0.438	+0.177	<.001	<.001	3	4
COAD	BVES →	+0.519	+0.262	<.001	<.001	3	4
CCRCC	TAGLN →	+1.022	+0.671	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001993 vs GALNT16 — HNSC

Explore this scatter interactively →