Regulation of systemic arterial blood pressure by norepinephrine-epinephrine

Across TCGA cell cohorts, RNA activity of the Regulation of systemic arterial blood pressure by norepinephrine-epinephrine pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DEPP1, TPST1, and TKT, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DEPP1 grouped by Regulation of systemic arterial blood pressure by norepinephrine-epinephrine-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DEPP1 →	+1.517	+1.130	.009	.001	3	5
UPPER_AERODIGESTIVE_TRACT	TPST1 →	+1.141	+1.481	.003	<.001	3	4
OVARY	TKT →	-1.316	-1.501	.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	TP53TG5 →	-0.390	-1.255	.003	.006	3	3
UPPER_AERODIGESTIVE_TRACT	RRAD →	+2.699	+1.269	.003	.004	3	3
OESOPHAGUS	POGLUT1 →	+0.833	+1.092	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DEPP1 by Regulation of systemic arterial blood pressure by norepinephrine-epinephrine activity — BLOOD_Leukemia

Explore this box plot interactively →