Regulation of systemic arterial blood pressure by circulatory renin-angiotensin

Across TCGA patient cohorts, RNA activity of the Regulation of systemic arterial blood pressure by circulatory renin-angiotensin pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPP1R12C, FERMT2, and KANK2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of systemic arterial blood pressure by circulatory renin-angiotensin activity versus PPP1R12C in UCEC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPP1R12C →	+0.481	+0.082	<.001	<.001	3	9
UCEC	FERMT2 →	+0.737	+0.110	<.001	<.001	3	9
UCEC	KANK2 →	+0.752	+0.094	<.001	<.001	3	8
BRCA	BYSL →	-0.310	-0.051	<.001	<.001	3	8
LUAD	KANK2_S540 →	+0.642	+0.089	<.001	<.001	3	8
UCEC	PRKG1 →	+0.719	+0.104	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001991 vs PPP1R12C — UCEC

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