Regulation of systemic arterial blood pressure by circulatory renin-angiotensin

Across TCGA cell cohorts, RNA activity of the Regulation of systemic arterial blood pressure by circulatory renin-angiotensin pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CMA1, ENPEP, and SUCNR1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CMA1 grouped by Regulation of systemic arterial blood pressure by circulatory renin-angiotensin-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CMA1 →	-0.367	-1.043	<.001	<.001	3	5
SKIN	ENPEP →	-0.262	-0.986	.003	<.001	3	5
BREAST	SUCNR1 →	-0.183	-0.822	<.001	.002	2	6
LUNG_NSCLC_LUAD	DCTD →	-0.094	-0.907	.001	<.001	3	4
BREAST	ATP6AP2 →	-0.377	-0.904	<.001	<.001	3	4
CNS	NME5 →	-0.188	-0.771	.004	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CMA1 by Regulation of systemic arterial blood pressure by circulatory renin-angiotensin activity — CNS

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