Regulation of systemic arterial blood pressure by circulatory renin-angiotensin

Across TCGA cell cohorts, RNA activity of the Regulation of systemic arterial blood pressure by circulatory renin-angiotensin pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NANOS3, TIMM17B, and EAPP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NANOS3 grouped by Regulation of systemic arterial blood pressure by circulatory renin-angiotensin-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	NANOS3 →	-0.536	-1.099	.007	.003	3	5
LUNG_SCLC	TIMM17B →	-0.604	-1.062	<.001	<.001	3	5
BLOOD_Lymphoma	EAPP →	-0.794	-1.894	.003	<.001	3	5
LARGE_INTESTINE	OGFOD2 →	-0.347	-0.835	.003	.001	3	5
UPPER_AERODIGESTIVE_TRACT	FAM120B →	-0.745	-1.086	.004	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	ATG13 →	-1.097	-1.212	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NANOS3 by Regulation of systemic arterial blood pressure by circulatory renin-angiotensin activity — KIDNEY

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