Regulation of systemic arterial blood pressure by circulatory renin-angiotensin

Across TCGA cell cohorts, RNA activity of the Regulation of systemic arterial blood pressure by circulatory renin-angiotensin pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NSUN6, DDOST, and CYFIP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of systemic arterial blood pressure by circulatory renin-angiotensin activity versus NSUN6 in BLOOD_Leukemia (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NSUN6 →	-0.684	-0.644	.008	.004	3	3
BLOOD_Leukemia	DDOST →	+0.887	+0.494	<.001	.003	3	3
BLOOD_Leukemia	CYFIP2 →	-2.524	-0.582	.001	.002	3	3
BLOOD_Leukemia	FNDC3B →	+1.811	+0.526	<.001	.002	3	3
LARGE_INTESTINE	BRD1 →	-0.619	-0.814	.001	.009	2	4
URINARY_TRACT	KRBA1 →	-0.622	-0.251	.009	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001991 vs NSUN6 — BLOOD_Leukemia

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