Regulation of systemic arterial blood pressure by hormone

Across TCGA patient cohorts, RNA activity of the Regulation of systemic arterial blood pressure by hormone pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DNTTIP2, ESF1, and F13A1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of systemic arterial blood pressure by hormone activity versus DNTTIP2 in BRCA (Pearson r = -0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DNTTIP2 →	-0.222	-0.037	<.001	<.001	3	8
OV	ESF1 →	-0.461	-0.041	<.001	.001	3	8
BRCA	F13A1 →	+0.623	+0.033	<.001	<.001	3	8
BRCA	KANK2 →	+0.631	+0.044	<.001	<.001	3	8
OV	MPHOSPH10 →	-0.360	-0.041	.001	<.001	3	8
BRCA	SYNM →	+0.682	+0.034	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001990 vs DNTTIP2 — BRCA

Explore this scatter interactively →