Regulation of systemic arterial blood pressure by hormone

Across TCGA cell cohorts, RNA activity of the Regulation of systemic arterial blood pressure by hormone pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM255B, TRADD, and COG1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM255B grouped by Regulation of systemic arterial blood pressure by hormone-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TMEM255B →	-2.441	-1.402	.001	<.001	3	4
BLOOD_Lymphoma	TRADD →	-1.464	-1.683	<.001	<.001	2	5
BLOOD_Lymphoma	COG1 →	-1.012	-1.740	.004	<.001	3	4
BLOOD_Myeloma	NOB1 →	+0.812	+1.324	.008	.001	3	4
LARGE_INTESTINE	UPK2 →	-2.867	-1.042	.003	.001	3	4
STOMACH	CST6 →	-3.867	-1.351	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM255B by Regulation of systemic arterial blood pressure by hormone activity — BONE

Explore this box plot interactively →